| 酒精对骨组织代谢影响机制的研究进展 |
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| 引用本文： | 申意伟,徐西林 张晓峰 李雪 吕航 谢欣昇 张骋 白洋 范桢亮. 酒精对骨组织代谢影响机制的研究进展[J]. 中国骨质疏松杂志, 2020, 0(2): 298-301 |
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| 作者姓名： | 申意伟 徐西林 张晓峰 李雪 吕航 谢欣昇 张骋 白洋 范桢亮 |
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| 作者单位： | 1.黑龙江中医药大学，黑龙江 哈尔滨 1500402.黑龙江中医药大学附属第二医院，黑龙江 哈尔滨 150001 |
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| 基金项目： | 国家自然科学基金项目（81774343, 81904222）;黑龙江省中医药科研项目(2018ZYY045);黑龙江中医药大学科研基金项目(201811);哈尔滨市应用技术研究与开发项目(2017RAXXJ047) |
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| 摘 要： | 饮酒现象几乎风靡全球,我国由于特有的饮酒文化已成为酒精性疾病高发的重灾区。酒精可对多种组织造成损伤,长期大量饮酒引起骨代谢紊乱、骨量丢失、骨微观结构退化致使骨脆性增加,使骨折和骨坏死风险增加。本文从酒精对骨组织细胞、细胞促炎因子、氧化应激、雌激素、甲状旁腺素-维生素D以及相关通路的影响综述了酒精与骨组织代谢的关系,归纳了酒精引起骨损伤的机制,以备参阅。
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| 关 键 词： | 酒精；骨质疏松症；骨坏死；骨代谢 |
Advances in research on the mechanism of alcohol on bone tissue metabolism |
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| Affiliation: | 1. Heilongjiang University of Chinese Medicine, Harbin 150040, China2. The Second Affiliated Hospital of Orthopaedics of Heilongjiang University of Chinese Medicine, Harbin 150040, China |
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| Abstract: | The phenomenon of drinking is almost universal, and due to the unique drinking culture China has become the hardest hit area for alcoholic diseases. Alcohol can cause damage to a variety of tissues. Long-term heavy drinking causes bone metabolism disorders, loss of bone mass, and deterioration of bone microstructure, resulting in increased bone fragility and increased risk of fracture and osteonecrosis. In this paper, the effects of alcohol on bone tissue cells, cellular pro-inflammatory factors, oxidative stress, estrogen, parathyroid hormone-vitamin D and related pathways were reviewed. The relationship between alcohol and bone metabolism was summarized. The mechanism of alcohol-induced bone injury was summarized. |
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| Keywords: | alcohol osteoporosis osteonecrosis bone metabolism |
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