| 纳洛酮对外伤性脑损伤患者血浆ET-1和CGRP影响的临床研究 |
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| 引用本文： | 张春银,官明,蔡亮,陈伯勋,甘西伦.纳洛酮对外伤性脑损伤患者血浆ET-1和CGRP影响的临床研究[J].标记免疫分析与临床,2009,16(3):139-141. |
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| 作者姓名： | 张春银 官明 蔡亮 陈伯勋 甘西伦 |
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| 作者单位： | 1. 泸州医学院附属医院核医学科,四川,泸州,646000
2. 泸州医学院附属医院神经外科,四川,泸州,646000 |
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| 摘 要： | 探讨外伤性脑损伤患者血浆ET-1和CGRP变化以及纳洛酮治疗对血浆ET-1和CGRP的影响。90例外伤性脑损伤患者随机分为纳洛酮治疗组与常规治疗组,另取30名健康人作为对照组。用放射免疫分析法测定患者治疗前后血浆ET-1、CGRP含量。纳洛酮治疗组和常规治疗组治疗前血浆ET-1显著升高,治疗后明显下降,常规治疗组下降幅度明显小于纳洛酮治疗组（P〈0.01）;纳洛酮治疗组和常规治疗组治疗后血浆CGRP明显升高,纳洛酮治疗组升高幅度明显大于常规治疗组（P〈0.01）。外伤性脑损伤患者血浆ET-1水平显著升高,CGRP水平显著降低;早期应用纳洛酮可显著降低ET-1和提高CGRP水平。初步研究显示,纳洛酮具有脑保护作用,伤后早期应用纳洛酮可改善病人预后。
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| 关 键 词： | 脑损伤 纳洛酮 内皮素 降钙素基因相关肽 |
The Effect of Naloxone on Plasma ET-1 and CGRP Levels in Patients with Traumatic Brain Injury |
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| ZHANG Chun-yin,GUAN Ming,CAI Liang,CHEN Bo-xun,GAN Xi-lun.The Effect of Naloxone on Plasma ET-1 and CGRP Levels in Patients with Traumatic Brain Injury[J].Labeled Immunoassays and Clinical Medicine,2009,16(3):139-141. |
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| Authors: | ZHANG Chun-yin GUAN Ming CAI Liang CHEN Bo-xun GAN Xi-lun |
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| Institution: | ZHANG Chun-yin,GUAN Ming,CAI Liang,CHEN Bo-xun,GAN Xi-lun(Department of Nuclear Medicine,The Affiliated Hospital of Luzhou Medical College,Luzhou 646000,China) |
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| Abstract: | To investigate the effect of naloxone on the changes of plasma ET-1 and CGRP levels in patients with traumatic brain injury,ninety patients with traumatic brain injury were randomly divided into naloxone treated group and conventionally treated group(both n=45).The plasma levels of ET-1 and CGRP in both groups before and after treatment and in 30 healthy controls were measured by RIA.The results showed that the plasma levels of ET-1 were significantly increased in the patient before treatment and decreased ... |
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| Keywords: | Traumatic brain injury Naloxone Endothelins Calctionin gene related peptide |
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