疏肝健脾汤治疗缺铁性贫血的临床研究

目的]观察疏肝健脾汤(由柴胡、陈皮、党参、黄芪、紫河车、阿胶、白术、山楂、大枣等中药组成)治疗缺铁性贫血(IDA)的临床疗效,并初步探讨其作用机制。方法]171例缺铁性贫血患者按就诊先后顺序分为治疗组和对照组.治疗组用疏肝健脾汤,对照组用硫酸亚铁,均连续用药4周,观察治疗后贫血症状、体征改善情况,并检测两组治疗前后血红蛋白(Hb)、红细胞(RBC)、血清铁蛋白(SF)等指标以评价两种药物对IDA的疗效。结果]两组治疗后IDA的症状、体征、贫血及缺铁状态均有不同程度改善(与治疗前比较P<0.01),治疗组促进IDA体征、贫血及缺铁状态的改善明显优于对照组(均P<0.01),且在治疗过程中未出现不良反应。结论]疏肝健脾汤治疗缺铁性贫血疗效优于硫酸亚铁。

Clinical Studies on Shugan Jianpi Decoction in Treating Iron-deficiency Anemia

Objective] To investigate the therapeutic effect of Shugan Jianpi Decoction , a formula mainly composed of Radix Bupleuri, Pericarpium Citri Reticulatae, Radix Codonopsis, Radix Astragali, Placenta Hominis, etc., in treating iron-deficiency anemia and to explore its mechanism. Methods] One hundred and seventy-one cases of iron-deficiency anemia were randomized to two groups: group A was treated with Shugan Jianpi Decoction and group B with ferrous sulfate for 4 weeks. Symptoms and signs of anemia were observed and levels of hemoglobin (Hb), red blood cells (RBC), mean corpuscular hemoglobin (MCH) and serum ferrin (SF) were detected before and after treatment to evaluate the effects of the two drugs. Results] The symptoms and signs of anemia were improved and levels of Hb, RBC, MCH and SF were increased after treatment in the two groups ( P < 0.01 compared with those before treatment); the above effects were better in group A than those in group B ( P < 0.01 ). No adverse reaction was found. Conclusion] Shugan Jianpi Decoction exerts an effect in treating iron-deficiency anemia and its effect is better that that of ferrous sulfate.