| APOE基因多态性与单相抑郁症无关联 |
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| 引用本文： | 汪栋祥,陆峥,施慎逊,钱伊萍,汤国梅,林嗣萃,江开达,江三多.APOE基因多态性与单相抑郁症无关联[J].上海精神医学,2001,13(2):77-79. |
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| 作者姓名： | 汪栋祥 陆峥 施慎逊 钱伊萍 汤国梅 林嗣萃 江开达 江三多 |
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| 作者单位： | 上海市精神卫生中心, |
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| 摘 要： | 目的 探讨APOE基因与单相抑郁症之间的关系。方法 以73例单相抑郁症患者为研究对象，80例健康人为对照组。用聚合酶链反应（PCR）扩增技术及限制性片段长度多态性（RFLPs)技术测定研究对象的APOE基因多态性。结果 发现单相抑郁症与APOE基因的多态性之间无关联。结论 APOE基因对上海汉族人群中单相抑郁症的病因可能不起重要作用。
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| 关 键 词： | 单相抑郁症 APOE基因 关联 多态性 |
| 修稿时间： | 2000年4月21日 |
A study of the association between unipolar depression and polymorphisms of APOE gene |
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| Wang Dongxiang,Lu Zheng,Shi Shenxun,et al..A study of the association between unipolar depression and polymorphisms of APOE gene[J].Shanghai Archives of Psychiatry,2001,13(2):77-79. |
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| Authors: | Wang Dongxiang Lu Zheng Shi Shenxun |
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| Institution: | Wang Dongxiang,Lu Zheng,Shi Shenxun,et al.,Shanghai Mental Health Center,Shanghai 200030 |
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| Abstract: | Objectives: To investigate the association between APOE gene and unipolar depression. Method: The genotypes and alleles of APOE gene in 73 unipolar depression patients and 80 healthy controls were examined with PCR and restriction fragment length polymorphisms (RFLPs) technique. Results : The polymorphisms of APOE gene were not associated with unipolar depression. Conclusion: Our results support the APOE gene may not play a major role in the pathogenesis of unipolar depression in Han population in Shanghai. |
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| Keywords: | Unipolar depression APOE gene Association |
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