| 人参茎叶皂甙及其单体对大鼠脑内B型单胺氧化酶活性的影响 |
| |
| 引用本文： | 张予阳,于庆海,吴春福.人参茎叶皂甙及其单体对大鼠脑内B型单胺氧化酶活性的影响[J].沈阳药科大学学报,1993(1). |
| |
| 作者姓名： | 张予阳 于庆海 吴春福 |
| |
| 作者单位： | 沈阳药学院中药药理学教研室
(张予阳，于庆海)，沈阳药学院中药药理学教研室(吴春福) |
| |
| 摘 要： | 本文用体外法研究了人参茎叶皂甙(GSLS)及其单体Rg_1,Rg_2,Re和Rh_1大鼠脑内B型单胺氧化酶(MAO-B)活性的影响。结果表明,GSLS和Rh_1可加强MAO-B的活性。Rg_1和Rg_2可抑制MAO-B的活性,其抑制强度与3.3×10~(-5)mg/ml优降宁相当。抑制特征曲线表明Rg_1和Rg_2对MAO-B的抑制作用均属竞争性抑制。
|
| 关 键 词： | 人参茎叶皂甙 人参皂甙Rg_1 Rg_2 R(?) Rh_1 大鼠 脑 B型单胺氧化酶 体外法 |
EFFECTS IN VITRO OF GINSENG STEM AND LEAF SAPONIN (GSLS) AND ITS MONOMERS ON BRAIN MONOAMINE OXIDASE B OF RATS |
| |
| Zhang Yuyang Yu Qinghai Wu Chunfu Dept. of Chinese Materia Medica Pharmacology.EFFECTS IN VITRO OF GINSENG STEM AND LEAF SAPONIN (GSLS) AND ITS MONOMERS ON BRAIN MONOAMINE OXIDASE B OF RATS[J].Journal of Shenyang Pharmaceutical University,1993(1). |
| |
| Authors: | Zhang Yuyang Yu Qinghai Wu Chunfu Dept of Chinese Materia Medica Pharmacology |
| |
| Institution: | Zhang Yuyang Yu Qinghai Wu Chunfu Dept. of Chinese Materia Medica Pharmacology |
| |
| Abstract: | The results of a study In vitro of the effects of GSLS and its monomers on brain inonoamine oxidase B(MAO-B) showed that GSLS and Rh_1 could increase the activity of MAO-B and and Rg_1,and Rg_2 could inhibit the activity of MAO-B. The inhibitory ratio wa about thirty percent. The peak of inhibitory intsensity of Rg_1 and Rg_2 was the same as was caused by 10~(-5)mg/ml pargyline. The inhibition of MAO-B by Rg_1 and Rg_2 showed competitive nature. No effect of Re on MAO-B was observed. |
| |
| Keywords: | Ginseng stem-leaf saponin Ginseng saponin Rg_1 Ginseng saponin Rg_2 Ginseng saponin Re Ginseng saponini Rh_1 Rat Brain Monoamine oxidase B In vitro |
| 本文献已被 CNKI 等数据库收录！ |
