小肠黏膜下层对大鼠创伤皮肤愈合的实验研究

【目的】为研究小肠黏膜下层对创伤皮肤愈合过程的影响。【方法】制备了小肠黏膜下层片剂。用SD大鼠建立全层皮肤缺损的创伤模型，分成小肠黏膜下层组、络合碘凡士林纱条组以及空白对照组，分阶段取材，宏观观察及组织学观察以上三组大鼠愈合过程。【结果】小肠黏膜下层贴附皮肤不引起排斥反应，无伤口感染。小肠黏膜下层组在愈合速度方面快于络合碘凡士林纱条，空白对照组最慢，小肠黏膜下层组愈合无瘢痕，皮肤附件生长良好，而其余二组瘢痕愈合，皮肤附件仅生长于伤口边缘处。【结论】小肠黏膜下层具有消炎、促肉芽组织生长和上皮组织生长作用，应用于皮肤创伤且能无疤愈合。

Experimental Study on Effects of Small Intestinal Submucosa on Healing of Rat Skin Wounds

Objectives]To investigate the effects of small intestinal submucosa on healing of rat skin wounds.Full skin lossing models of SD rats were established and their small intestinal submucosa tablets were prepared. Forty-eight SD rats were divided randomly into 3 groups, each included 16 rats: Group A,skin wounds were bound up with small intestinal submucosa ; Group B, bound up with iodoform vaseline gauze; Group C, served as blank controls. Specimens were collected from the wounds at several stages, the healing process in 3 groups was observed grossly and histologically.The small intestinal submucosa adhered to the wound did not cause immune reaction and infection. As for the speed of healing, wound under small intestinal submucosa was the fastest, then under the iodoform vaseline gauze, blank controls came to the last. Scars were not found around the wounds bound up with small intestinal submucosa and the skin accessories also grew well ; while the wounds in rest two groups were healed with scars and the skin accessories only grew on the margins of wounds.Conclusion]Small intestinal submucosa can eliminate inflammation , promote growth of granulation tissue and epithelium tissue. Furthermore, the treated wounds heal without scars.