Inhibition of bone resorption in cultures of mouse calvariae by apicularen A |
| |
Authors: | Hong JangJa Sasaki Hirokazu Niikura Kazuaki Yanai Maiko Nakano Yasuhiro Yokomakura Aya Ishihara Kenji Hirasawa Noriyasu Kang Young-Sook Oh Joa Sub Kwak Jong Hwan Zee OkPyo Ohuchi Kazuo |
| |
Affiliation: | Laboratory of Pathophysiological Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan. |
| |
Abstract: | Apicularens A and B were isolated from the myxobacterial genus Chondromyces apiculatus JW184. Apicularen A inhibited bafilomycin A1-sensitive ATP-dependent proton transport into microsome vesicles more potently than apicularen B. Bone resorption in cultures of mouse calvariae induced by human parathyroid hormone (PTH) or interleukin-1beta (IL-1beta) was inhibited by apicularen A at 10 and 100 nM, while apicularen B had no effect. The bisphosphonate incadronate inhibited bone resorption at 100 nM, being less effective than apicularen A. Our findings indicate that apicularen A inhibits bone resorption induced by PTH or IL-1beta more potently than apicularen B, probably due to inhibition of the V-ATPase. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|