Exogenous NGF restores endogenous NGF distribution in the brain of the cognitively impaired aged rat |
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| Authors: | Albeck Dave Mesches Michael H Juthberg Sonya Browning Michael Bickford Paula C Rose Gregory M Granholm A-Ch |
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| Affiliation: | Department of Psychology, University of Colorado at Denver, Campus Box 173, P.O. Box 173364, 80217-3364, USA. dalbeck@carbon.cudenver.edu |
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| Abstract: | Alzheimer's disease and normal aging may impair retrograde transport of nerve growth factor (NGF) from cortical areas to basal forebrain cholinergic neurons. We demonstrate a relationship between performance in a spatial reference memory task and NGF distribution in the aged rat brain. In addition, exogenous NGF restored endogenous NGF distribution in cognitively impaired aged rats. These data suggest that NGF administration restores utilization of endogenous growth factor in the brain of cognitively impaired aged rats. |
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| Keywords: | Nerve growth factor Cholinergic neuron Basal forebrain Hippocampus |
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