| 凋亡素:一种诱导肿瘤特异性细胞凋亡的病毒蛋白 |
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| 引用本文： | 章应慧,屈伸.凋亡素:一种诱导肿瘤特异性细胞凋亡的病毒蛋白[J].医学分子生物学杂志,2004,1(2):63-68. |
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| 作者姓名： | 章应慧 屈伸 |
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| 作者单位： | 莱顿大学自然科学院,荷兰,莱顿;华中科技大学同济医学院基础医学院生物化学与分子生物学系,武汉,430030 |
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| 摘 要： | 本文对肿瘤特异性细胞凋亡素(apoptin)的研究进展,包括Apoptin的肿瘤特异性细胞凋亡效应和肿瘤治疗应用研究、Apoptin的生物物理和生物化学特性、Apoptin的凋亡功能区域以及细胞核定位对Ap-optin肿瘤特异性凋亡效应的重要性、Apoptin相关蛋白质、肿瘤特异性磷酸激酶对Apoptin的激活作用及正常细胞对Apoptin的中和机制等进行了综述,讨论了Apoptin的激活与肿瘤发生过程的相关性及Apoptin作为一种特异性肿瘤杀手用于肿瘤治疗和作为一种肿瘤特异性感应蛋白用于肿瘤发生研究的前景。
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| 关 键 词： | 凋亡素 细胞凋亡 磷酸激酶 磷酸化 肿瘤发生 |
| 修稿时间： | 2004年4月20日 |
Apoptin,A Tumor-Specific Viral Death Effector |
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| ZHANG Yinghui,QU Shen,Mathieu H. M. Noteborn
Leiden University,Leiden,The Netherlands.Apoptin,A Tumor-Specific Viral Death Effector[J].Journal of Medical Molecular Biology,2004,1(2):63-68. |
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| Authors: | ZHANG Yinghui QU Shen Mathieu H M Noteborn
Leiden University Leiden The Netherlands |
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| Institution: | ZHANG Yinghui,QU Shen,Mathieu H. M. Noteborn
Leiden University,Leiden,The Netherlands
Department of Biochemistry and Molecular Biology,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430030,China |
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| Abstract: | This review will mainly focus on the recent studies on the tumor-specific viral death effector Apoptin, including the tumor-specificity of Apoptin, utility of Apoptin in cancer therapy, biophysical and biochemical properties of Apoptin, death effect domains and importance of nuclear localization for Apoptin-induced apoptosis, Apoptin-associated proteins, activation of Apoptin by its tumor-specific kinase, and the normal-cell neutralization of Apoptin. The relativity of Apoptin activation and tumorigenesis, and the perspectives of Apoptin as a tumor-specific killer for cancer therapy and as a sensor for the basic study of tumorigenesis, will also be discussed. |
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| Keywords: | Apoptin apoptosis kinase phosphorylation tumorigenesis |
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