中国女性脑卒中发病危险因素的Meta分析

目的 综合评价我国女性脑卒中发生的危险因素。方法 应用meta分析的方法对国内有关女性脑卒中发病危险因素的研究结果进行定量综合分析;运用Revman5.1进行异质性检验以及合并OR值和95%可信区间的计算。结果 被动吸烟、肥胖及口服避孕药与女性脑卒中关系的分别为OR=2.11,95%CI=1.19～3.74,P<0.05;OR=1.18;95%CI=1.01～1.38,P<0.05;OR=1.64,95%CI=1.18～2.28,P<0.05,差异有统计学意义, 敏感性分析结果提示,3个因素采用不同模型的meta分析结果均一致。结论 现有的有限证据表明,被动吸烟、肥胖及口服避孕药是中国女性脑卒中发病的危险因素。

Meta-analysis of stroke risk factors among Chinese women

Objective To evaluate stroke risk factors in Chinese women.Methods A comprehensive quantitative analysis was conducted by Meta analysis method, on the domestic research results of stroke risk factors of Chinese women .Using RevMan5.1 test for heterogeneity was performed, pooled OR value and 95% confidence interval calculated.Results The pooled OR values of the relationship of passive smoking, obesity, oral contraceptives were OR 2.11,95%CI 1.19-3.74,P=0.01;OR 1.18;95%CI 1.01-1.38,P=0.04;OR 1.64,95%CI 1.18-2.28,P=0.003,respectively, and there were significant differences. The analytical result of sensitivity proved that the results of Meta-analysis were coherent.Conclusion The available evidence suggested that passive smoking, obesity and oral contraceptives are the risk factors for stroke in Chinese women.