亚临床甲状腺功能减退症与动脉粥样硬化的相关性

目的 探讨亚临床型甲状腺功能减退症(subclinicalhypothyroidism, SCH)与动脉粥样硬化之间的关系。方法 选取SCH患者80例,同时选取甲状腺功能正常的健康志愿者80例作为对照组,比较两组甲状腺功能相关指标:促甲状腺激素(TSH) 、血清游离三碘甲腺原氨酸(FT3)、血清游离甲状腺素(FT4);动脉粥样硬化相关指标:高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、甘油三酯(TG)、血栓素B2(TXB2)、C反应蛋白(CRP)、颈动脉中层厚度(cIMT)的变化,并对各指标的相关性进行研究。结果 SCH组TSH、LDL-C、TC、TXB2及cIMT明显高于对照组(P<0.01);Pearson相关分析显示,TSH与TC、LDL-C、TXB2、cIMT呈正相关;多元线性回归分析结果显示,cIMT与LDL-C、TSH独立相关。结论 SCH患者血清中高水平TSH与动脉粥样硬化的发生存在一定的相关性。

Relationship analysis between subclinical hypothyroidism and atherosclerosis

Objective To explore the relationship between subclinical hypothyroidism (SCH) and atherosclerosis.Methods Eighty patients with SCH and eighty volunteers with euthyroidism were contained in the study as SCH group and control group, respectively. All indicators were examined as follows:thyroid function-related indicators such as TSH, FT3 and FT4; atherosclerosis-related indicator such as HDL-C,LDL-C,TC,TG,TXB2,CRP and cIMT. Correlation study was performed between indicators.Results The levels of TSH, LDL-C, TC and TXB2 in SCH group were significantly higher than those of control group(P<0.01). Pearson correlation analysis showed that TSH level was positively correlated with TC, LDL-C, TXB2 and cIMT level. Multivariate regression analysis showed that cIMT was independently correlated with LDL-C and TSH.Conclusion There appeared some correlation bteween the high level of TSH in patients with SCH and the development of atherosclerosis