系统性红斑狼疮诊断与治疗

系统性红斑狼疮(SLE)是由自身免疫介导的,以血清中出现多种自身抗体为特征的自身免疫性疾病。其发病机制复杂,可累及多系统多器官,临床表现多样,病程迁延反复,病因至今尚未完全明确。近年来,随着对SLE认识的逐步深入,国内外对该疾病的诊断和治疗水平都在不断完善和提高,SLE患者的预后显著改善。本文对SLE的诊断及治疗进展进行综述,旨在提高对SLE疾病监测、管理水平及改善预后。

Advances in diagnosis and therapy of systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a prototypical systemic autoimmune disease that affects multiple organs and is characterized by the presence of variety of autoantibodies， episodic flares and elevated mortality despite therapy. The etiology of SLE remains poorly known. In recent years， a wide range of mechanisms directed researches are being developed， coupled with the progress of diagnostic performance and treatment， as well as remarkable improvement in prognosis. Here， we provide an update on the development of classification criteria and treatment regimens of SLE，aiming to improve the monitoring， management and， ultimately， the prognosis of SLE.