成人霍奇金淋巴瘤69例临床预后分析

目的 探讨霍奇金淋巴瘤(HL)的临床特点与预后的关系。方法 回顾2004年1~12月在我院初治的69例成人HL患者的临床资料,分析各临床特征与预后的关系。结果 ①50例(72.5%)患者以颈部淋巴结肿大起病,病理以混合细胞型最多见。②治疗有效率达76.8％(53/69)。5年总生存率及无失败生存率分别为80.0%和72.0%。③单因素分析显示年龄、分期、结外器官侵犯、脾大、淋巴瘤国际预后指数(International Prognostic Index,IPI)分组、血红蛋白、一线化疗方案、化疗疗程、缓解情况是影响生存的主要因素(P＜0.05)。④多因素分析显示缓解情况是影响HL患者生存的主要因素(P＜0.05)。结论 HL患者以颈部淋巴结肿大起病最常见,治疗后缓解情况是HL独立预后危险因素。

Clinical prognostic analysis on 69 cases of adult Hodgkin lymphoma

Objective To explore the clinical characteristics and prognosis of Hodgkin lymphoma(HL).Methods The clinical data of 69 adult patients with HL treated at our hospital from Jan. 2004 to Dec. 2014 were analyzed retrospectively,analyzing the clinical characteristics with prognosis.Results ①50 patients (72.5%) had cervical lymph nodes involvement in the pre-treatment evaluation.Pathological study revealed that mixed cellularity was most common.②The response rate was 76.8%(53/69). The rates of 5-years overall survival rate and failure free survival were 80.0% and 72.0%.③Kaplan-Meier single-factor analysis showed that age,clinical staging,extra nodal tissues involvement, splenomegaly,International Prognostic Index(IPI) grouping, hemoglobin, first-line chemotherapy regimens,chemotherapy course, remission were the main factors influencing the survival (P<0.05).④Cox model multivariate analysis indicated that remission was the main factor affecting the survival (P<0.05).Conclusion Cervical lymph node was the most common involvement site with HL. Remission was the independent prognosis risk factor for HL.