Liver adenomatosis: serial investigation on MRI |
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Authors: | Saowanee Srirattanapong Wirana Angthong Bong Soo Kim Paul Hideyo Hayashi David A. Gerber John T. Woosley Jared Peacock Anuruddika Ranatunga Richard C. Semelka |
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Affiliation: | 1. Department of Radiology, University of North Carolina at Chapel Hill, Old Clinic Bldg, CB 7510 – 2001, Chapel Hill, NC, 27599-7510, USA 2. Department of Diagnostic and Therapeutic Radiology Ramathibodi Hospital, Mahidol University, Bangkok, Thailand 3. Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA 4. Division of Abdominal Transplant, Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA 5. Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA 6. Department of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
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Abstract: | Purpose To describe the natural history of liver adenomatosis (LA), including complications and changes in lesion size over time. Materials and methods Eighteen patients with clinical diagnosis of LA were included. Clinical and biochemical information were collected. The initial and follow-up MR studies were reviewed retrospectively to determine change in lesion size and imaging features. Results Seventeen patients were women (94.4%). The mean age of the initial MR study was 37.0 years (18–52 years). The median size of the largest lesion was 6.7 cm (range 3.0–13.5 cm). Intratumoral bleeding was detected on MRI in 9 lesions, in 7 patients (38.8%). The median size for hemorrhagic lesions was 7.6 cm (range 4.1–13.5 cm). During the mean follow-up period of 29.4 (range 4–98) months, 10 patients had stable disease (55.6%), and 8 patients had tumor regression (44.4%). Of 8 patients who were followed without intervention, 3 patients (37.5%) had spontaneous regression. No malignant transformation or lesion progression was occurred. Conclusion During an over 2-year follow-up period, the majority of lesions of LA appeared to remain stable or showed tumor regression. Spontaneous tumor regression can be observed in approximately 37% of individuals in the age range of 28–53 years. |
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