| 尼索地平自微乳制剂稳定性的影响因素 |
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| 引用本文： | 刁雨辉,仝新勇,周建平.尼索地平自微乳制剂稳定性的影响因素[J].中国医院药学杂志,2007,27(2):215-218. |
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| 作者姓名： | 刁雨辉 仝新勇 周建平 |
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| 作者单位： | 1. 南京大学医学院附属鼓楼医院,江苏,南京,210008
2. 中国药科大学,江苏,南京,210009 |
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| 摘 要： | 目的：研究影响尼索地平自微乳制剂稳定性的因素。方法：以温度、稀释倍数、稀释递质种类、絮凝剂及反絮凝剂为主要影响因素，采用测定微乳粒子大小及其分布、Zeta电位进行综合评价。结果：本自微乳制剂对稀释倍数、稀释递质种类、絮凝剂及反絮凝剂敏感，但对温度不敏感，且粒径稳定。结论：本自微乳制剂质量稳定，但稀释后的微乳稳定性下降。
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| 关 键 词： | 尼索地平 自微乳 稳定性 |
| 文章编号： | 1001-5213(2007)02-0215-04 |
| 修稿时间： | 2006-04-11 |
Study on the influence factors for stability of nisoidipine self-microemulsifying drug delivery system |
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| DIAO Yu-hui,TONG Xin-yong,ZHOU Jian-ping.Study on the influence factors for stability of nisoidipine self-microemulsifying drug delivery system[J].Chinese Journal of Hospital Pharmacy,2007,27(2):215-218. |
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| Authors: | DIAO Yu-hui TONG Xin-yong ZHOU Jian-ping |
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| Institution: | 1. The Affiliated Drum Tower Hospital of Nanjing University, Jiangshu Nanjing 210008,China;2. College of Pharmacy,China Pharmaceutical University,Jiangshu Nanjing 210009,China |
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| Abstract: | OBJECTIVE To study the influence factors for stability of Nisoldipine Self-microemulsifying drug delivery system(SMDDS).METHODS Zeta electric potential,the particle size and distribution of Nisoldipine SMDDS were determined and estimated while the temperature,dilution method,medium types,flocculant and deflocculant as major influence factors.RESULTS The Nisoldipine SMDDS was insensitive to temperature and had stable particle size and distribution.But it was sensitive to dilution method,medium types,flocculant and deflocculant.CONCLUSION The quality of Nisoldipine SMDDS was stable,but the stability of Nisoldipine microemulsion was decreased after dilution. |
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| Keywords: | nisoldipine self-microemulsifying DDS stability |
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