Decreased right and left ventricular myocardial performance in obstructive sleep apnea |
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Authors: | Romero-Corral Abel Somers Virend K Pellikka Patricia A Olson Eric J Bailey Kent R Korinek Josef Orban Marek Sierra-Johnson Justo Kato Masahiko Amin Raouf S Lopez-Jimenez Francisco |
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Institution: | Division of Cardiovascular Diseases, Gonda 5-368, Mayo Clinic College of Medicine, Mayo Foundation, 200 First St SW, Rochester MN 55905, USA. |
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Abstract: | BACKGROUND: Obstructive sleep apnea (OSA) may predispose patients to congestive heart failure (CHF), suggesting a deleterious effect of OSA on myocardial contractility. METHODS: A cross-sectional study of 85 subjects with suspected OSA who had undergone their first overnight polysomnogram, accompanied by an echocardiographic study. Patients were divided according to the apnea-hypopnea index as follows: < 5 (control subjects); 5 to 14 (mild OSA); and >or= 15 (moderate-to-severe OSA). Right and left ventricular function was evaluated using the myocardial performance index (MPI) and other echocardiographic parameters. For the right ventricle analyses, we excluded patients with a Doppler pulmonary systolic pressure of >or= 45 mm Hg, while for the left ventricle we excluded patients with an ejection fraction of
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