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Advances in three-dimensional reconstruction of the experimental spinal cord injury |
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| Authors: | B S C L V D K N R B |
| Institution: | a Department of Basic Medical Sciences, School of Veterinary Medicine, Center for Paralysis Research, Purdue University, 1244 VCPR West Lafayette, IN 47907-1244, USA b Department of Computer Sciences, Center for Computational Visualization, The University of Texas at Austin, Austin, TX, USA c Lawrence Livermore National Laboratory Livermore, CA, USA d Computational Engineering International, Morrisville, NC, USA e Foundry Networks, Inc. San Jose, CA, USA |
| Abstract: | Three-dimensional (3D) computer reconstruction is an ideal tool for evaluating the centralized pathology of mammalian spinal cord injury (SCI) where multiple anatomical features are embedded within each other. Here, we evaluate three different reconstruction algorithms to three-dimensionally visualize SCIs. We also show for the first time, that determination of the volume and surface area of pathological features is possible using the reconstructed 3D images themselves. We compare these measurements to those calculated by older morphometric approaches. Finally, we demonstrate dynamic navigation into a 3D spinal cord reconstruction. |
| Keywords: | Three-dimensional reconstruction 3D Computer visualization 3D Morphometry Spinal cord injury Neurotrauma Serial light microscopy Registration |
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