| 紫杉醇致大鼠外周神经病理性疼痛模型的建立 |
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| 引用本文： | 陈治军,田玉科,罗放,曹菲,王平.紫杉醇致大鼠外周神经病理性疼痛模型的建立[J].华中科技大学学报(医学版),2008,37(6). |
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| 作者姓名： | 陈治军 田玉科 罗放 曹菲 王平 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院麻醉科,武汉,430030 |
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| 摘 要： | 目的探讨建立紫杉醇致大鼠外周神经病理性疼痛模型的可行性。方法40只成年雄性SD大鼠随机分为4组，各组均在第1、3、5、7天腹腔注射紫杉醇，剂量分别为0、0．5、1．0、2．0mg／（kg·d），分别于用药前和用药后第3、5、7、12、16、20和25天测定大鼠的机械缩足反射阈值（MWT）和热缩足潜伏期（TWL），用药后第20天采用透射电镜观察坐骨神经超微结构。结果腹腔注射紫杉醇1．0mg／kg组大鼠最早在用药的第5天出现机械痛敏和热痛敏，机械痛阈在用药的第12天达到最小，而热痛阈在用药的第16天达到最小。腹腔注射紫杉醇1．0mg／kg组大鼠的坐骨神经纤维髓鞘板层结构松散、肿胀变形、排列紊乱、厚薄不均。结论使用SD大鼠重复腹腔注射1．0mg／kg紫杉醇的方法可以成功建立紫杉醇致大鼠外周神经病理性疼痛模型。
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| 关 键 词： | 紫杉醇 神经病理痛 动物模型 |
Establishment of an Animal Model of Peripheral Neuropathic Pain Induced by Paclitaxel in Rats |
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| Chen Zhijun,Tian Yuke,Luo Fang et al.Establishment of an Animal Model of Peripheral Neuropathic Pain Induced by Paclitaxel in Rats[J].Journal of Huazhong University of Science and Technology(Health Sciences),2008,37(6). |
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| Authors: | Chen Zhijun Tian Yuke Luo Fang |
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| Institution: | Chen Zhijun,Tian Yuke,Luo Fang et al Department of Anesthesiology,Tongji Hospital,Tongji Medical College,Huazhong University of Science , Technology,Wuhan 430030 |
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| Abstract: | Objective To investigate the feasibility of establishing an animal model of peripheral neuropathic pain induced by paclitaxel in rats. Methods Forty adult male SD rats were randomly divided into 4 groups (n=10 in each group). The rats were injected intraperitoneally on 4 alternate days (days 1,3,5 and 7) with vehicle or paclitaxel (0.5,1.0 or 2.0 mg/kg). Mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) of rats' hind paw were measured before and 3,5,7,12,16,20 and 25 days after inje... |
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| Keywords: | pacitaxel neuropathic pain animal model |
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