Monoamine oxidase inhibition by the MAO-A inhibitors brofaromine and clorgyline in healthy volunteers |
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| Authors: | Priv.-Doz. Dr. C. H. Gleiter B. Mühlbauer R. M. Schulz E. Nilsson K. H. Antonin P. R. Bieck |
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| Affiliation: | (1) Human Pharmacology Institute, Ciba-Geigy GmbH, Tübingen, Germany;(2) Present address: Abteilung Klinische Pharmakologie, Zentrum für Pharmakologie und Toxikologie der Universität, Robert-Koch-Straße 40, D-37075 Göttingen, Germany |
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| Abstract: | Summary The present study compared the extent and duration of MAO inhibition by the selective and reversible MAO-A inhibitor brofaromine with the selective and irreversible MAO-A inhibitor clorgyline using amine pressor tests and excretion of urinary amine metabolites (MHPG, tryptamine). The pharmacological characterization of clorgyline as an irreversible and brofaromine as a reversible MAO-A inhibitor in clinically effective doses was confirmed in humans. |
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| Keywords: | Monoamine oxidase brofaromine clorgyline pressor test healthy volunteers |
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