碱性成纤维细胞生长因子联合胶原蛋白海绵治疗重度渗血创面的应用研究

目的探讨碱性成纤维细胞生长因子联合胶原蛋白海绵应用于传统方法治疗效果不佳的重度渗血创面的止血和促进创面愈合的效果。方法选择148例不同类型但均具有难以缝扎和植皮的重度渗血创面的创伤患者，随机均分为两组，即碱性成纤维细胞生长因子联合胶原蛋白海绵治疗组（联合组，74例〉和传统压迫、包扎等常规方法治疗组（对照组，74例）。观察两组患者伤后第2、4、6d创面愈合的效果并进行统计学分析。结果伤后第2天时联合组平均无渗血创面为24．77％，对照组为17．73％；第4d时联合组平均无渗血创面为51．49％，对照组为25．87％；第6d时联合组平均无渗血创面为76．94％，对照组为49．94％。在各时相点两组创面的止血和愈合程度均有非常显著差别（P〈0．01）。结论碱性成纤维细胞生长因子联合胶原蛋白海绵对传统方法疗效不佳的重度渗血创面止血、愈合有显著的促进作用，且起效早，速度快，明显优于传统治疗方法，值得进一步推广应用。

Treatment of serious blooding wound surface with basic fibroblast growth factor and collagen sponge

Objective To investigate the effect of basic fibroblast growth factor and collagen sponge to treat serious blooding wound surface. Methods 148 patients with serious blooding wound surface were randomly divided into two groups, including associated group （using basic fibroblast growth factor and collagen sponge, 74 cases） and control group （using common treatment, 74 cases）. The treatment effects on 2, 4, 6 days after injured were observed. Results The average non-blooding wound surface area/whole wound surface area of associated group on 2, 4, 6 days after injured were 24.77%, 51.49% and 76.94%, respectively, whereas that of the control group were 17. 73%, 25. 87% and 49. 94%, respectively. There was very remarkable difference between the two groups （P〈0.01）. Conclusions It is more effective and faster to treat serious blooding wound surface with basic fibroblast growth factor associated with collagen sponge than that with common methods.