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强心康治疗慢性充血性心力衰竭的临床疗效
引用本文:蔡少杭,陈晖,刘雪娜,洪朝章,卢武生. 强心康治疗慢性充血性心力衰竭的临床疗效[J]. 海南医学院学报, 2009, 15(11): 1416-1417
作者姓名:蔡少杭  陈晖  刘雪娜  洪朝章  卢武生
作者单位:[1]福建省漳州市中医院 [2]中国人民解放军175医院,福建漳州363000
基金项目:海南医学院科研基金资助学报项目 
摘    要:目的:探讨强心康治疗慢性心力衰竭的临床疗效。方法:选择慢性充血性心力衰竭20例,均予吸氧、强心、利尿、扩张血管,包括血管紧张素转换酶抑制剂、β受体阻滞剂等治疗,在此基础上加用强心康,每次4片,每天3次,1个月为1疗程。用药前、后测定尿液水通道蛋白2及血浆肾脏精氨酸加压素。结果:治疗前、后水通道蛋白2分别为(387.9±102.6)、(206.7±49.21);血浆肾脏精氨酸加压素分别为(50.36±15.63)、(30.19±11.46)。经统计学分析,差异有统计学意义(P〈0.01)。结论:强心康在陵性心力衰竭的治疗中不仅只是改善临床症状、提高生活质量,更重要的是在增加心脏收缩功能,逆转心室重构,减少水钠潴留,从根本上阻断慢性心衰发展。

关 键 词:强心康  慢性心力衰竭  水通道蛋白2  心功能

Effect of Qiangxin-kang on chronic congestive heart failure
Affiliation:CAI Shao-hang, CHEN Hui, LIU Xue-na, HONG Chao-zhang, LU Wu-sheng(1. Hospital of TCM in Zhangzhou City; 2. No. 175 Hospital of PLA Zhangzhou 3630001, China)
Abstract:Objective:To explore the clinic effect of Qiangxin-kang on chronic congestive heart failure.Methods:Selected 20 cases with chronic congestive heart failure,and treated them with oxygen inhalation,cardiotonic therapy,diuresis therapy,dilating vessel agent including angiotensin converting enzyme inhibitor,β-blocker and so on.Besides,Qiangxin-kang was administrated at 4 tables per time,3 times a day,with 1 month as a course.Determined urinary excretion of aquaporin-2 water channel protein(AQP-2)and arginine vasopressin(AVP).Results:The result showed AQP-2 before and after treatment were(387.9±102.6)and(206.7±49.21),respectively;AVP were(50.36±15.63)and(30.19±11.46),with statistic significant difference(P<0.01).Conclusion:Qiangxin-kang can strengthen heart contract function,reverse ventricular remodeling,and reduce retention of water and sodium to block the progress of chronic heart failure,improve the clinic symptoms and life quality.
Keywords:Qiangxin Kang  Chronic heart failure  Aquaporin2  Cardiac function
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