Malignant blue naevus with distant subcutaneous metastasis |
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Authors: | R BÖNI R PANIZZON RAMUCH BÖNI H STEINERT R DUMMER |
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Institution: | Departments of Dermatology, University Hospital of Zurich, Gloriastrasse 31, 8049 Zurich, Switzerland;Departments of Radiology, University Hospital of Zurich, Gloriastrasse 31, 8049 Zurich, Switzerland |
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Abstract: | Malignant blue naevus is a distinct but rarely documented variant of malignant melanoma, and we describe the triple recurrence of a suprapatellar cellular blue naevus over 12 years in a middle-aged woman. Staging investigations revealed a distant subcutaneous metastasis of the right thigh. Immunohistochemistry of the primary lesion and all recurrences showed S-100, HMB-45, NK1/C-3 and Ki-67 positive cells. However, non-malignant cellular blue naevi from five consecutive other patients were all Ki-67 negative. The change from negative to positive Ki-67 responsivity may therefore be a valuable marker of malignant and metastatic potential in early cellular blue naevi. |
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