川乌与白芍配伍的免疫调节作用初探

目的 :研究川乌配伍白芍的免疫调节作用。方法 :检测小鼠迟发性超敏反应 (DTH)、大鼠免疫变态反应性炎症、单核巨噬细胞 (MΦ)吞噬功能和特异性抗体生成等。结果与结论 :在本文实验条件下 ,乌芍配伍对细胞免疫有明显的双向调节作用 ,既可显著抑制正常和免疫增高小鼠DTH ,明显抑制大鼠佐剂继发性关节炎 ,又能明显提高免疫低下的小鼠MΦ吞噬功能。与之相比 ,各单味药的调节作用较弱。根据风湿痹证免疫调节紊乱的病理机理 ,本文结果可能是临床应用乌芍配伍治疗风湿痹证的重要机制之一。

Studies on Immunoregulating Effect of Monkshood Root and Peony Root Used Singly and in Combination

Objective: To investigate the abirritation and antiinflammation effects of Monkshood Root and Peony Root used singly and in combination, and to find the enhanced effects of the two drugs used in combination; To observe the effect of Monkshood Root and Peony Root used singly and in combination by studing the immunoregulation function in experimental animals. Method: The response of delayed type hypersensitivity in mice, the phagocytosis of abdominal macrophages in mice,and the production of special antibodies in mice were observed. Result: The two drugs used in combination could increase phagocytosic function of mononuclear macrophagocyte in hypoimmuitic model mice, and inhibit the responses of delayed type hypersensitivity in the hyperimmunitic model mice and the nonimmunosuppressive treated mice, with nosignificant effect on the production of special antibodies in mice. Conclusion: In accordance with the mechanism of the disorder between the anti inflammation effect and the induce inflammation effect on arthritis in the immune system, these data show the bidirectional effect of the two drugs used in combination on the immune responses, which may be one of the main mechanisms of treating arthralgia due to wind dampness.