瑞芬太尼和芬太尼在无痛人流术中应用的比较研究

目的 对异丙酚复合瑞芬太尼在人流术中的情况进行系统的观察。以评价其镇静效果和安全性。方法 需行人流术女性患者45例，随机分成三组：芬太尼组。瑞芬太尼2ng组。瑞芬太尼3ng组，每组15例，观察麻醉和手术中异丙酚用量、术后恢复时间、体动、呼吸抑制和术后腹痛情况等。结果 术中异丙酚的总用量芬太尼组〉瑞芬太尼2ng组〉瑞芬太尼3ng组，各组间均有显著差异；术后恢复时间以瑞芬太尼2ng组最快，芬太尼组和瑞芬太尼3ng恢复较慢；术后的呼吸抑制在瑞芬太尼的两组中所有患者均有发生，明显高于芬太尼组；三组体动发生情况相似，无显著差异；术后腹痛的发生情况，芬太尼组最多，瑞芬太尼两组相仿。结论 靶控输注瑞芬太尼在人流术中有一定的优点，但需注意术中的呼吸管理，从综合效应看效应部位浓度2ng／ml优于3ng／ml。

The Effect of Remifentanil and Fentany in Painless Induced Abortion

objective To investigate the efficacy and safety of painless induced abortion with a combined use of propofol and remifentanil.Methods Fourty five patients undergoing elective abortion were divided into three groups:the fentanyl group,remifentanil 2ng group and remifentanil 3ng group.Several factors including the dose of propofol,recovery time after anesthesia,body movement,respiration weakness and post-operation bellyache etc were observed.Results The total doses of propofol during anesthes in the fentanyl group was greater than that in the remifentanil 2ng group and the latter was greater than that in the remifentanil 3ng group;The recovered time in the remifentanil group was quicker than that in the fentanyl group and remifentanil 3ng group.Respiration weakness was appeared in all two groups in the of remifentanil and body movement was similar in the three groups;Compared with two remifentanil groups,the rate of post-operation bellyache in fentanyl group was increased significantly.Results Target-controlled infusion of remifentanil used in painless induced abortion had some advantage, but attention must be paid to respiration management.Compared with the dose of 3ng/ml remifentanil,2ng/ml remifentanil had some advantages.