| 四脑室注射阿片肽及GABA能系统拮抗剂对心血管活动的影响 |
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| 引用本文： | 吴建华,丁虎,杨焜. 四脑室注射阿片肽及GABA能系统拮抗剂对心血管活动的影响[J]. 华中科技大学学报(医学版), 1987, 0(2) |
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| 作者姓名： | 吴建华 丁虎 杨焜 |
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| 作者单位： | 同济医科大学基础医学部生理学教研室(吴建华，丁虎)，同济医科大学基础医学部生理学教研室(杨焜) |
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| 摘 要： | 实验用健康家兔,在四脑室注射给药,研究了内源性阿片肽与内源性GABA在低位脑干的心血管调节作用。结果提示:①在四脑室周围结构中,内源性阿片肽与内源性GABA对静息心血管功能与压力反射性心血管变化都有紧张性控制作用。②内源性GABA对静息心血管功能的控制比内源性阿片肽强。③内源性阿片肽抑制颈动脉加压反应,内源性GABA增强此反应。
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| 关 键 词： | 心血管调节 颈动脉阻塞 交感神经放电 内源性阿片肽 :内源性GABA |
Effects of Opioid Peptidergic and GABAergic Antagonists Injected into the Fourth Cerebral Ventricle on the Cardiovascular Function |
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| Wu Jianhua,Ding Hu,Yang Kun. Effects of Opioid Peptidergic and GABAergic Antagonists Injected into the Fourth Cerebral Ventricle on the Cardiovascular Function[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 1987, 0(2) |
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| Authors: | Wu Jianhua Ding Hu Yang Kun |
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| Affiliation: | Wu Jianhua,Ding Hu,Yang KunDepartment of Physiology,Faculty of Basic Medical Sciences,Tongji Medical University,Wuhan |
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| Abstract: | By injecting drugs into the fourth cerebral ventricle of rabbits, we studied the effects of endogenous opioid peptides and GABA on cardiovascular regulation in the lower brain stem. The results indicated: (1) both endogenous opioid peptides and GABA in the structures around the fourth cerebral ventricle exert a tonical action on resting and reflex cardiovascular functions. (2) The endogenous GABA has a stronger action on resting cardiovascular function than the endogenous opioid peptides. (3) the endogenous opioid peptides inhibit the carotid artery occlusion pressor response, whereas the endogenous GABA enhances it. |
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| Keywords: | Cardiovascular regulation carotid artery occlusion sympathetic nerve discharge endogenous opioid peptides endogenous GABA |
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