Enhanced platelet aggregation, high homocysteine level, and microvascular disease in diabetic muscle infarctions: implications for therapy |
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Authors: | Rajkumar V Ragatzki P Sima A Levy J |
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Affiliation: | (1) Department of Medicine, Wayne State University School of Medicine, Detriot, MI;(2) Department of Pathology, Wayne State University School of Medicne, Detriot, MI;(3) Division of Endocrinology, University Health Center-4H, 4201 St. Antoine, 48201 Detriot, MI |
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Abstract: | Muscle infaction is a rare complication in patients with diabetes mellitus, probably because of the rich vascular supply of this tissue. We describe a patient with type 1 diabetes who had infarction of the muscles in her right thigh. We report, for the first time, that the patient, in addition to an advanced microvascular disease in the muscle, had increased plasma total homocysteine levels and increased platelet aggregation. These pathologies might have a synergistic effect on the development of this rare complication and should be treated aggrssively to prevent further episodes. |
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Keywords: | Diabetes homocysteine muscle infarction folic acid aspirin |
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