Toxicity and Response Evaluation of the Interferon Inducer Poly ICLC Administered at Low Dose in Advanced Renal Carcinoma and Relapsed or Refractory Lymphoma: A Report of Two Clinical Trials of the Eastern Cooperative Oncology Group |
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Authors: | Bruce J. Giantonio Howard Hochster Ronald Blum Peter H. Wiernik Gary R. Hudes John Kirkwood Donald Trump Martin M. Oken |
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Affiliation: | (1) University of Pennsylvania, Philadelphia, Pennsylvania, USA;(2) New York University Medical Center, New York, New York, USA;(3) Albert Einstein College of Medicine, Bronx, New York, USA;(4) Fox Chase Cancer center, Philadelphia, Pennsylvania, USA;(5) University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA;(6) Virginia Piper Cancer Institute, Minneapolis, Minnesota, USA |
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Abstract: | Purpose: Phase II studies were conducted toevaluate the safety and efficacy of the interferon inducerPoly ICLC at low doses in advanced renal cancer and relapsedor refractory lymphoma. Patients and methods:Twenty-nine patients with advanced renal carcinoma and elevenpatients with lymphoma were treated with poly ICLC. Patientsreceived 0.25 mg/m2 of poly ICLC intravenouslytwice weekly three days apart until progression orunacceptable toxicity. Results: There were noobjective responses. Six patients with renal carcinoma hadstable disease as best response with one patient receiving 62weeks of therapy. Toxicity included grade 3 anemia in 8patients and grade 4 anemia in one patient. All patients wereanemic prior to entry with a median grade 2 anemia atbaseline. Grade 4 neutropenia, thrombocytopenia and injectionsite pain occurred in one patient each. Grade 3 fever, chillsor fatigue occurred in four, three, and three patientsrespectively. Any grade fever occurred in 10 patients(25.6%) and any grade chills occurred in 9 patients(23.1%). Conclusion: Poly ICLC at this doseand schedule is well tolerated in both patient populations andis inactive in renal carcinoma. |
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Keywords: | poly I-C interferon inducers renal carcinoma lymphoma |
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