大豆异黄酮对大鼠前列腺增生的抑制作用

目的 :探讨补充不同剂量大豆异黄酮对大鼠前列腺增生的影响。方法 :应用丙酸睾酮诱导大鼠前列腺增生 ,观察正常对照组、模型组、低剂量、中剂量及高剂量大豆异黄酮组大鼠前列腺的湿重、前列腺指数、形态学、前列腺特异性酸性磷酸酶及酸性磷酸酶改变。结果 :①低、中、高剂量组大鼠前叶前列腺湿重及前列腺指数、前列腺特异性酸性磷酸酶均显著低于模型组 (P <0 .0 5 ) ;②中、高剂量组大鼠前叶前列腺湿重及前列腺指数和前列腺特异性酸性磷酸酶均显著低于低剂量组 (P <0 .0 5 )。结论 :大豆异黄酮可显著抑制大鼠前列腺增生 ,抑制酸性磷酸酶水平的升高 ,且呈剂量依赖性。大豆异黄酮可能对预防和辅助治疗良性前列腺增生有一定作用。

Inhibitive effect of soybean isoflavone on prostate hyperplasia in rats

Objective To explore the inhibitive effect of soybean isoflavone on benign prostatic hyperplasia in rats. Methods By subcutaneously injecting testosterone propionate to induce prostate hyperplasia in rats, the changes of prostate wet weight, prostatic index, morphological change, prostate-specific acid phosphatase (PAP), acid phosphatase in the control,the model,low,moderate,high dose of soybean isoflavone groups were observed.Results The ventral prostate wet weight, prostatic index,and PAP in the low, moderate,and high dose groups were significantly lower than those in the models (P<0.05). The ventral prostate wet weight, prostatic index,and PAP in the moderate,and high dose groups were significantly lower than those in the low dose group (P<0.05). Conclusion Soybean isoflavone inhibits prostate hyperplasia and the increase of acid phosphatase and PAP in a dose- dependent manner in rats. Soybean isoflavone may serve as supplementary therapy and prevent benign prostatic hyperplasia.