2型糖尿病患者高尿酸血症与代谢综合征的相关性

目的研究2型糖尿病患者中血清尿酸水平在代谢综合征发病中的作用，探讨其可能的发病机制。方法627例2型糖尿病患者按血清尿酸水平分两组：高尿酸水平组77例，非高尿酸组（尿酸水平偏低或正常组）550例，观察血清尿酸水平与代谢综合征主要参数的相关性。结果血尿酸与血压、甘油三酯、体质指数呈正相关（P〈0．01），与高密度脂蛋白胆固醇呈负相关（P〈0.01）；代谢综合征患病率高尿酸组为74．03％，非高尿酸组为48．00％（P〈0．01）。结论2型糖尿病患者血尿酸水平与多因素相关，提示2型糖尿病高尿酸血症可能是代谢综合征等发病的危险因素之一。

Relationship between Serum Uric Acid Level and the Metabolic Syndrome in Type 2 Diabetes

Objective To study the effect of serum uric levels on the metabolic syndrome and its pathogenesis.Methods 627 cases were divided into 2 groups according to their uric acid levels,and then the relationship between serum uric acid and the chief parameters of the metabolic syndrome were observed.Results There was a positive correlation between uric acid levels and blood pressure,triglycerides,body mass index(P<0.01),and a negative correlation between uric acid levels and HDL-cholesterol(P<0.01).The prevalence of metabolic syndrome was higher in patients with hyperuricaemia than those without it(P<0.01).Conclusion There were many factors related to serum uric acid levels in type 2 diabetic patients,it suggested that hyperuricemia might be one of the risk factors for metabolic syndrome.