| 胃癌组织中CD4+、CD25+调节性T淋巴细胞的表达及意义 |
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| 引用本文： | 田琳,刘明娜,胡立华,陈学英,蔡宇.胃癌组织中CD4+、CD25+调节性T淋巴细胞的表达及意义[J].中国医师杂志,2009,11(4). |
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| 作者姓名： | 田琳 刘明娜 胡立华 陈学英 蔡宇 |
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| 作者单位： | 1. 黑龙江省医院消化内科,黑龙江,哈尔滨,150036
2. 哈尔滨医科大学附属第二医院消化内科 |
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| 摘 要： | 目的 探讨CD4+、CD25+调节性T淋巴细胞在胃癌患者胃组织中的表达及意义.方法 利用流式细胞仪对76例胃癌及癌旁组织中的CD4+、CD25+调节性T淋巴细胞与CD8+T淋巴细胞进行定量及量化关系分析.结果 CD4+、CD25+调节性T淋巴细胞的阳性率在胃癌、癌旁组织、正常时照组分别为(11.2±0.9)%、(6.4±1.1)%、(4.1±0.8)%.癌组织与癌旁组织和对照组比较,差异有统计学意义(t=2.03、2.05,P<0.05).在肿瘤组织,随着CD4+、CD25+调节性T淋巴细胞的增加,CD8+T淋巴细胞出现了快速减少趋势.而在癌旁组织中却没有此现象出现.结论 CD4+、CD25+调节性T淋巴细胞通过对CD8+T淋巴细胞的抑制参与胃癌细胞抗肿瘤免疫的作用.
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| 关 键 词： | 胃肿瘤/免疫学 CD4阳性T淋巴细胞 受体 白细胞介素2 T淋巴细胞 |
Expression of CD4+, CD25+ regulatory T cells and its significance in carcinoma of stomach |
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| TIAN Lin,LIU Min-na,HU Li-hua,CHEN Xue-ying,CAI Yu.Expression of CD4+, CD25+ regulatory T cells and its significance in carcinoma of stomach[J].Journal of Chinese Physician,2009,11(4). |
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| Authors: | TIAN Lin LIU Min-na HU Li-hua CHEN Xue-ying CAI Yu |
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| Abstract: | Objective To study the expression of CD4+, CD25+ regulatory T cells and its significance in carcinoma of stomach. Methods Flow cytometry was used to quantify and analyze the results of CD4+, CD25 + regulatory T cells and CD8+ T cells in 76 patients with gastric cancer. Results CD4+, CD25+ regulatory T cells expression in gastric cancer tissue, adjacent tissues and control group are (1.2±0.9) %, (6.4±1.1) % and (4.1±0.8) %. The results have statistical significance (P<0.05). CD8+ T cells markedly de-creased in gastric cancer tissue, while CD4+ , CD25+ regulatory T cells increased. But this manifest did not happen in adjacent tissues.Conclusion CD4+, CD25+ regulatory T cells suppress gastric cancer though inhibiting CD8+ T cells. |
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| Keywords: | Stomach neoplasms/IM CD4-positive T-lymphocytes Receptors interleukin-2 T-lymphocytes |
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