危重新生儿全身炎症反应综合征和多器官功能不全综合征的临床分析

目的：探讨危重新生儿全身炎症反应综合征（SIRS）及多器官功能不全综合征（MODS）的预后及影响因素，方法：回顾性总结分析我院新生儿重症监护病房（NICU），于1997年1月－1999年12月收治的危重生儿，根据Hayden修订的ＳＩＲＳ诊断标准和全国小儿急诊学组拟定的ＭＯＦ诊断标准进行临床分析，结果：２５２例危重儿，符合ＳＩＲＳ诊断标准的１６１例，占６３．９％，最终发展为ＭＯＤＳ的８４例，占５２。２％，死亡３２例，病死率为３８．１％，产伤、窒息、患儿成熟度及胎烘羊水污染易发展为ＭＯＤS,死亡率显高于非ＭＯＤＳ组，结论：ＳＩＲＳ和ＭＯＤＳ在ＮＩＣＵ中发生率和病死率均高，而围产因素严重影响其预后，必须早期干预。

Clinical analysis of systemic inflammatory response syndrome and multiple organ dysfunction syndrome in neonate with critical illness

Objective To evaluate the prognosis and the relation between systemic inflammatory response syndrome(SIRS)and multiple organ dysfunction syndrome (MODS)in neonatal intensive care units(NICU).Methods According to the criteria of SIRS by Hayden and MOF by Chinese Pediatric Emergency Association,252 critical illness were studied from January 1997 to December 1999.Results Among 252 critical newborn,161 cases (64%) were diagnosed as SIRS,84 cases(84/161) developed MODS,32 died,the mortality rate of MODS was 38 1%.The risk factors of MODS included birth trauma,degree of asphyxia,gestational age and meconium-stained amniotic fluid,which were associated with an increased risk of to MODS.The mortality in MODS was higher than that in non-MODS group.Conclusion SIRS/MODS is common in NICU and its mortality high.The prognosis is related with perinatal factors.We believe that early intervention should be taken in such cases.