DuoVisc黏弹剂在外伤性白内障超声乳化术中对角膜伤口和角膜内皮保护作用的临床观察

目的:观察黏弹性物质DuoVisc在外伤性白内障超声乳化术中对角膜伤口水肿及角膜内皮的保护作用。方法:外伤性白内障138眼,随机分成2组,其中透明质酸钠组69眼,DuoVisc组69眼,两组患者在外伤前无眼病史、无内眼手术史,无糖尿病等全身疾病史。采用超声乳化白内障摘除联合折叠人工晶状体植入术,术前、术后用超声测厚仪测量角膜厚度。结果:两组患者年龄,角膜伤口大小、形态,角膜水肿情况,超声能量与时间的乘积无明显差异;两组患者术前角膜厚度无明显差异。透明质酸钠组患者术后1,7,30,90d角膜厚度分别比术前增大18.9%,7.0%,4.5%,3.9%,均有显著性差异(P<0.05);DuoVisc组术后角膜厚度1d比术前增大11.9%,有显著性差异(P<0.05),术后7,30,90d角膜厚度分别比术前增大2.8%,1.5%,0.8%,无显著性差异。结论:在外伤性白内障超声乳化术中使用黏弹剂DuoVisc对角膜伤口及角膜内皮细胞具有明显的保护作用。

Clinical evaluation of the protective effect of DuoVisc on corneal cut and corneal endothelium in traumatic cataract phacoemulsification

·AIM:To observe the protective effect of DuoVisc on the corneal cut and corneal endothelium in traumatic cataract phacoemulsification.·METHODS:One hundred and thirty-eight eyes of traumatic cataract patients were randomly divided into 2 groups:Sodium Hyaluronate group 69 eyes and DuoVisc group 69 eyes.Both the two groups had no eye disease history,ocular operation history,systemic disease history such as diabetes mellitus.All the patients underwent phacoemulsification combined with folded intraocular lens implantation,and the thickness of the cornea were measured by ultrasonic thickness gauge before and after the operation.·RESULTS:There were no statistically significant diffe-rences between the two groups in age,size and morph-ous of coneal cut,state of corneal edema,cross product of ultrasonic energy with time,so was preoperative corneal thicknesses of the two groups.Corneal thickn-esses 1 day,7,30,90 days after operation in Sodium Hyaluronate group increased by 18.9%,7.0%,4.5%,3.9% respectively,compared with that of the preoperative(P<0.05),and there were statistically significant diffe-rences in all of them(P<0.05).For DuoVisc group,corneal thicknesses 1 day after operation increased by 11.9% compared with that of the preoperative,and the differences were significant(P<0.05).Corneal thick-nesses 7,30,90 days after operation increased by 2.8%,1.5%,0.8% respectively,compared with that of the preo-perative,but the differences were not significant.·CONCLUSION:DuoVisc seems to have apparently protective effect for coneal cut and endothelial cell in phacoemulsification for the treatment of traumatic cataract.·