| Abstract: | The patient with post-traumatic stress disorder (PTSD) may be incapacitated by anxiety, sleep disturbances, and other difficulties. Ten patients with PTSD received imipramine for two to three weeks and, at the end of the study, reported significantly decreased severity of intrusion items such as forced recollections, and sleep and dream disturbances, along with cessation of flashbacks in three of four patients with them. Most avoidance items did not decrease noticeably in severity. Imipramine, in combination with psychotherapy, may be an effective treatment strategy for patients with PTSD. Double-blind investigations are warranted. |
