胃癌及癌前病变中Survivin和 COX-2蛋白的表达及其与Hp感染的关系

目的]分析胃癌及癌前病变survivin、COX-2蛋白表达与幽门螺杆菌(Helicobacter pylori,Hpylori)感染的关系,探讨胃癌发病的可能机制。方法]收集胃癌标本51例,非癌胃黏膜标本47例,应用快速尿素酶试验与W-S银染色法将各种病变分为Hp感染阳性组和阴性组,应用免疫组化SP法对各种病变survivin、COX-2蛋白的表达进行检测。采用χ2检验进行数据分析。结果]Survivin蛋白的表达从慢性浅表性胃炎(CSG)到胃癌(GC)逐渐增加,其中慢性萎缩性胃炎(CAG)组明显低于肠化生(IM)、不典型增生(Dys)和胃癌(GC)组(Survivin 30.5%vs60.0%、62.5%、70.6%,P<0.05),而IM、Dys组与GC组差异无显著性意义(P>0.05);COX-2蛋白在CSG、CAG、IM、Dys、GC中的表达率分别为0%、23.1%、60.0%、50.0%、68.6%。其中,CAG组亦明显低于IM、Dys、GC组(P<0.05),而IM、Dys组与GC组差异无显著性意义(P>0.05)。在GC组,Hp阳性者Survivin、COX-2表达明显高于Hp阴性者(S...

Expressions of Survivin,COX-2 in GPL and gastric carcinoma and their association with helicobactor pylori infection

Objective] To observe expressions of survivin and COX-2 in gastric carcinoma and gastric precancerous lesion(GPL) and further elucidate the possible effect of Helicobacter pylori(H pylori) infection on gastric carcinoma pathogenesis.Methods] Collect gatric carcinoma samples 51 cases and non-cancer gastric mucosa 47 cases.Rapid urease test and Warthin-Starry method were used for examing H pylori infection of these patients.The expressions of survivin and COX-2 were examined by immunohistochemical SP techni...