Oleandrin suppresses activation of nuclear transcription factor-kappa B and activator protein-1 and potentiates apoptosis induced by ceramide |
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| Authors: | Sreenivasan Yashin Sarkar Abira Manna Sunil Kumar |
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| Affiliation: | Laboratory of Immunology, Centre for DNA Fingerprinting & Diagnostics, Nacharam, Hyderabad 500 076, India. |
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| Abstract: | |
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| Keywords: | AP-1, activator protein-1 CE, cytoplasmic extract Ceramide, N-acetyl- smallcaps" >d-sphingosine DOC, deoxycholate FBS, fetal bovine serum Mn-SOD, manganese superoxide dismutase MTT, 3-(4,5-dimethyl-2-thiozolyl)-2,5-diphenyl-2H-tetrazolium bromide NE, nuclear extract NIK, NF-κB-inducing kinase oleandrin, trans-3,4′,5-trihydroxystilbene PARP, poly(ADP-ribose) polymerase PBMC, peripheral blood mononuclear cells PIS, pre-immune serum ROI, reactive oxygen intermediate SEAP, secretory alkaline phosphatase TBA, thiobarbituric acid |
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