Restricted access to myeloid cells explained |
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| Authors: | Planelles Vicente |
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| Affiliation: | Division of Microbiology and Immunology, Department of Pathology, School of Medicine, University of Utah, Emma Eccles Jones Building, 15 North Medical Drive East 2100, Room 2520, Salt Lake City, UT 84112, USA. vicente.planelles@path.utah.edu |
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| Abstract: | The lentiviral accessory protein, Vpx, is known to counteract a restriction factor that is specific to myeloid cells, such as macrophages and dendritic cells. This review summarizes the findings in two seminal studies that identify SAMHD1 as the cellular protein that is responsible for myeloid cell restriction, and establish the existence of other types of restriction in these cells. |
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| Keywords: | Vpx DCAF-1 SAMHD1 ubiquitin Cullin4 HIV SIV macrophage dendritic cell myeloid cell |
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