The significance of cytoplasmic inclusions in late infantile and juvenile amaurotic idiocy |
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Authors: | Javad Towfighi Henry W Baird Pierluigi Gambetti Nicholas K Gonatas |
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Institution: | (1) Division of Neuropathology, University of Pennsylvania School of Medicine, 447 Johnson Pavilion, 19104 Philadelphia, Penna, USA |
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Abstract: | Summary The electron microscopic findings of cerebral biopsies from two siblings with late infantile-juvenile amaurotic idiocy are presented. One patient had a mixture of fingerprint and multilamellar inclusions, often in the same cytosome. The second patient had only fingerprint inclusions.Electron microscopic findings in autopsied tissues from two other cases of late infantile-juvenile amaurotic idiocy with multilamellar cytosomes are also presented. Evolution of the multilamellar cytosomes into lipofuscin was not observed. We concluded that cases of late infantile-juvenile amaurotic idiocy with multilamellar and fingerprint inclusions should be distinguished from cases with lipofuscin.The present investigation was supported by Research Grants NS 05572-08, 1 T01 NS 05712-01 and RR 75. |
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Keywords: | Juvenile Amaurotic Idiocy Multilamellar Crescentic fingerprint gif" alt="ldquo" align="MIDDLE" BORDER="0">fingerprint " target="_blank">gif" alt="rdquo" align="MIDDLE" BORDER="0"> Inclusions Lipofuscin |
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