| 子宫内膜癌患者血清中HE4、YKL-40的表达及临床意义 |
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| 引用本文： | 张雪玉,杨彩虹,吕娟. 子宫内膜癌患者血清中HE4、YKL-40的表达及临床意义[J]. 现代妇产科进展, 2011, 20(5): 377-380 |
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| 作者姓名： | 张雪玉 杨彩虹 吕娟 |
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| 作者单位： | 宁夏医科大学附属医院妇科,银川,750004 |
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| 基金项目： | 2010年宁夏科技攻关项目 |
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| 摘 要： | 目的:探讨血清人附睾蛋白4(HE4)、甲壳质酶蛋白40(YKL-40)在子宫内膜癌的表达及临床意义。方法:用酶联免疫吸附试验检测健康妇女、子宫内膜增生及子宫内膜癌患者血清中HE4、YKL-40的水平。结果:(1)健康妇女、子宫内膜增生患者及子宫内膜癌患者术前血清中HE4表达中位数分别为15.75、30.12、105.67pmol/L;YKL-40的表达中位数分别为39.6、42.8、100.5μg/L;子宫内膜癌组HE4、YKL-40的表达水平均高于前两组,差异有统计学意义(P<0.05),前两组的差异无统计学意义;子宫内膜癌患者术后血清中HE4、YKL-40中位数分别为23.52pmol/L、30.9μg/L,明显低于术前(P<0.05);(2)子宫内膜癌患者术前血清HE4浓度、YKL-40浓度与FIGO分期呈正相关关系。结论:子宫内膜癌血清HE4、YKL-40水平升高,可作为子宫内膜癌血清学标记物,是子宫内膜癌的早期辅助诊断、疗效评估、随访检测的客观指标,可用于指导临床的综合治疗。
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| 关 键 词： | 子宫内膜癌 人附睾蛋白4 甲壳质酶蛋白40 |
Expressions and significance of serum HE4 and YKL-40 in patients with endometrial cancer |
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| Zhang Xueyu,Yang Caihong,Lü Juan. Expressions and significance of serum HE4 and YKL-40 in patients with endometrial cancer[J]. Current Advances In Obstetrics and Gynecology, 2011, 20(5): 377-380 |
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| Authors: | Zhang Xueyu Yang Caihong Lü Juan |
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| Affiliation: | Zhang Xueyu,Yang Caihong,Lü Juan.Department of Gynecology,Affiliated Hospital of Ningxia Medical University,Shengli Street 804,Yinchuan 750004 |
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| Abstract: | Objective:To explore the expressions and significance of serum human epididymis protein 4(HE4),YKL-40 in patients with endometrial cancer.Methods:The enzyme-linked immuno-sorbent assay(ELISA)technique was applied to detect serum HE4 and YKL-40 levels in healthy women and patients with endometrial hyperplasia,and endometrial cancer.Results:(1)In healthy women,patients with endometrial hyperplasia,preoperative endometrial cancer,the serum HE4 median levels were 15.75,30.12,105.67pmol/L respectively.The serum ... |
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| Keywords: | Endometrial carcinoma YKL-40 HE4 |
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