12例肝炎性肌纤维母细胞瘤手术治疗的回顾性分析

目的：探讨肝炎性肌纤雏母细胞瘤（HIMT）的诊断和治疗经验。方法：回顾性分析2000年1月至2007年8月收治的12例HIMT患者的临床、病理学和影像学资料。结果：12例患者中男7例，女5例，中位年龄27．5岁（19～70岁）。患者多无明显临床症状，血清AFP检查正常，肝功能均为ChildA级；CT扫描有一定的特征性表现；3例通过超声引导下穿刺活检确诊，其余9例术前未获明确诊断。12例患者均行手术切除后病理检查确诊，肿瘤均为单发，直径2～12cm，均无明显包膜，无围术期死亡。9例术后随访10个月～6年，均未见肿瘤复发或转移。结论：HIMT的诊断依赖于临床、实验室和影像学检查，术前很难明确诊断。鉴于HIMT是一种低度恶性肿瘤，建议早期手术治疗。

Hepatic Inflammatory Myofibroblastic Tumor:a Retrospective Analysis of 12 Cases

Objective： To summarize on our experiences with diagnosis and treatment of hepatic inflammatory myofibroblastic tumor （ HIMT ）. Methods： From January 2000 to August 2007, clinical, pathological and imaging findings of 12 cases with HIMT comfirmed by operation were analyzed retrospectively. Results：The patients comprised 7 men and 5 women with a median age of 27.5 years. Most of the cases did not present with typical clinical symptoms. The liver function was all classified as Child-pugh class A, and serum level of AFP was within normal range. CT study captured some features characteristic of HIMT. Before operation, definite diagnosis was made in only 3 cases who underwent ultrasound-guided biopsy using percutaneous liver puncture but not in the other 9. All the patients underwent surgery. The gloss pathology showed non-capsulated, single masses, 2 - 12cm in diameter. No peri-operative death occurred. No local relapse or metastases were noted in 9 patients who were followed up for a period of 10 months to 6 years. Conclusion ：The preoperative diagnosis of HIMT can be difficult and depends largely on clinical data, laboratory test and radiography. Early surgery is recommended for HIMT which is recognized with low malignancy potential.