Two immunohistochemically identified populations of calcitonin gene-related peptide (CGRP)-immunoreactive axons in human skin |
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Authors: | I.L. Gibbins D. Wattchow B. Coventry |
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Affiliation: | 1. Department of Urology, University Clinic Hospital of Valencia, Universitat de València, Valencia, Spain;2. Department of Pathology, Universitat de València, Valencia, Spain;3. Biostatistic Department, IIS La Fe, Valencia, Spain;4. Department of Urology, University Clinic Hospital of Valencia. Surgery Department, Universitat de València, Valencia, Spain;1. Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan;2. Department of Advanced Transplant and Regenerative Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan;3. Department of Urology, Aomori Rosai Hospital, Hachinohe, Japan;4. Department of Urology, Mutsu General Hospital, Mutsu, Japan |
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Abstract: | Double labelling immunofluorescence has shown two populations of unmyelinated sensory axons in human skin that contain immunoreactivity (IR) to calcitonin gene-related peptide (CGRP). One population also contains IR to substance P (SP), whilst the other also contains IR to somatostatin (SOM). Axons containing both CGRP-IR and SOM-IR comprised more than 75% of CGRP-IR axons associated with the epidermis; the rest of the CGRP-IR axons contained SP-IR. No axons contained both SP-IR and SOM-IR. Some dermal blood vessels were surrounded by axons containing both CGRP-IR and SP-IR, but most CGRP-IR perivascular axons contained SOM-IR without SP-IR. Sweat glands were well supplied with sensory axons containing CGRP-IR and weak SOM-IR but not SP-IR. Therefore, CGRP is a histochemical marker for a larger number of unmyelinated cutaneous afferents in human skin than is SP. CGRP itself may have a role in the mediation of responses to stimulation of at least two populations of sensory axons. |
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Keywords: | Calcitonin gene-related peptide Substance P Somatostatin Sensory neuron Skin Human Immunofluorescence |
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