| 芳酰基氟尿嘧啶衍生物的合成及其抗肿瘤活性 |
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| 引用本文： | 孙昌俊,李洪祥,戚聿新. 芳酰基氟尿嘧啶衍生物的合成及其抗肿瘤活性[J]. 中国药物化学杂志, 2000, 10(3): 164-167 |
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| 作者姓名： | 孙昌俊 李洪祥 戚聿新 |
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| 作者单位： | 山东大学化学系,济南 |
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| 摘 要： | 采用２－取代－５－氟－３Ｈ－４－嘧啶酮与芳酰氯在丙酮中于三乙胺存在下反应，合成了１７个２－取代－３－芳酰基－５－氟－４－嘧啶酮类化合物。目标化合和的的结构经ＩＲ、＾１Ｈ－ＮＭＲ、元素分析或ＭＳ确定，初步生物活性测定显示，部分化合物具有一定的抗肿瘤活性。
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| 关 键 词： | 5－氟尿嘧啶 抗肿瘤化合物 合成 抗肿瘤活性 |
A Study on the Syntheses of Acy1-5-fluorouracil Derivatives and their Antitumor Activities |
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| Sun Changjun,LiHongxiang,Qi Yuxin,Li Aixia,(. A Study on the Syntheses of Acy1-5-fluorouracil Derivatives and their Antitumor Activities[J]. Chinese Journal of Medicinal Chemistry, 2000, 10(3): 164-167 |
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| Authors: | Sun Changjun LiHongxiang Qi Yuxin Li Aixia ( |
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| Affiliation: | Sun Changjun,LiHongxiang,Qi Yuxin,Li Aixia,(Department of Chemistry,Shandong University,Ji |
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| Abstract: | Seventeen 2 substituted 3 acyl 5 fluoro 4 pyrimidone compounds were prepared by the reaction of 2 substituted 5 fluoro 3 H 4 pyrimidones with acyl chloride in acetone in the presence of triethylamine.Their structures were confirmed by IR, 1H NMR,elementary analysis or MS.The preliminary antitumor tests showed that some of them exhibited certain antitumor activities. |
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| Keywords: | fluorouracil antitumor compound synthesis |
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