Contrast‐Enhanced Sonography for Monitoring Neoadjuvant Chemotherapy in Soft Tissue Sarcomas |
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| Authors: | Mittul Gulati MD James S Hu MD Bhushan Desai MD Darryl H Hwang PhD Edward G Grant MD Vinay A Duddalwar MD |
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| Institution: | 1. Department of Radiology, University of Southern California Keck School of Medicine, Los Angeles, California USA.;2. Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, California USA. |
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| Abstract: | Neoadjuvant chemotherapy is a mainstay in treating soft tissue sarcomas. Soft tissue sarcomas can show an increase in size and central necrosis, with a decrease in the viable tumor, as an initial response to neoadjuvant chemotherapy. Thus, the maximum tumor diameter may not reliably assess the response to this therapy. Contrast‐enhanced sonography may address this limitation. We evaluated 4 patients with soft tissue sarcomas by contrast‐enhanced sonography, performed concomitantly with conventional imaging (computed tomography, magnetic resonance imaging, or positron emission tomography). Quantitative analysis was also performed on 1 sarcoma. A viable, enhancing tumor versus tumor necrosis was nearly identical on contrast‐enhanced sonography and conventional imaging. Preliminary results demonstrate potential for contrast‐enhanced sonographic monitoring of soft tissue sarcomas during neoadjuvant chemotherapy. |
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| Keywords: | contrast-enhanced sonography neoadjuvant chemotherapy quantitative analysis soft tissue sarcoma |
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