Effect of macrophage-derived factor on hypoferraemia induced by Japanese encephalitis virus in mice. |
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| Authors: | M Bharadwaj N Khanna A Mathur and U C Chaturvedi |
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| Institution: | Postgraduate Department of Microbiology, K.G. Medical College, Lucknow, India. |
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| Abstract: | Depression of serum iron following Japanese encephalitis virus (JEV) infection was observed in mice. The hypoferraemia was associated with the accumulation of iron in reticulo-endothelial cells in the spleen. Splenectomy (compared with sham-operation) prevented the depression in serum iron concentration after JEV infection. It also prevented the rise in levels of liver iron. The effect of JEV-stimulated, splenic macrophage-derived factor (MDF) was evaluated in causing hypoferraemia. MDF produced a rapid reduction in the serum iron levels with accumulation of iron in spleen. These observations suggest that MDF plays a key role in the regulation of iron metabolism during JEV infection. |
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| Keywords: | Japanese encephalitis virus hypoferraemia cytokines macrophage-derived factor |
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