血浆与红细胞不同比例输注对大量失血患者凝血功能及预后的影响

目的探讨血浆与红细胞不同比例输注对大量失血患者凝血功能及预后的影响。方法选取我院2017年2月至2019年1月期间收治的102例大量失血患者,随机分为A、B、C组各34例。A组、B组、C组的FFP∶RBCs比例分别为1∶3、1∶2、1∶1,对比三组的凝血功能、液制品使用情况及预后。结果输血前,三组的aPTT、PT、Fbg水平比较无统计学差异(P>0.05)。输血后,三组的aPTT、PT均延长,且A组>B组>C组,差异有统计学意义(P<0.05);三组的Fbg水平均降低,且C组>B组>A组(P均<0.05)。FFP使用量:A组>B组>C组(P<0.05)。三组的RBCs、血小板及冷沉淀使用量比较无统计学差异(P>0.05)。三组的住院时间、治愈率及病死率比较无统计学差异(P>0.05)。结论对大量失血患者进行输血时,可将血浆与红细胞的输注比例控制为1∶1,有利于预防凝血功能障碍,且不会对患者预后造成严重影响。

Influence of Different Proportion of Plasma and Red Blood Cell Infusion on the Coagulation Function and Prognosis in Patients with Massive Blood Loss

Objective To analyze the influence of different proportion of plasma and red blood cell infusion on the coagulation function and prognosis in patients with massive blood loss.Methods 102 cases of patients with massive blood loss admitted to our hospital from February 2017 to January 2019 were selected and randomly divided into group A,group B and group B,with 34 cases in each group.The proportion of FFP∶RBCs in group A,group B and group C were respectively 1∶3,1∶2 and 1∶1.The coagulation function,the use of liquid products and prognosis were compared among the three groups.Results Before blood transfusion,no statistical difference was found in aPTT,PT and Fbg levels among the three groups(P>0.05).After blood transfusion,the aPTT and PT prolonged in three groups,with group A>group B>group C(all P<0.05).After blood transfusion,the Fbg levels in three groups decreased,with group C>group B>group A(all P<0.05).The FFP dosage of group A was higher than that of group B and group C,and the FFP dosage of group B was higher than that of group C(all P<0.05).No statistical difference was found in the RBCs,platelet and cold precipitation dosage among the three groups(P>0.05).No statistical difference was found in the hospitalization time,cure rate and mortality among the three groups(P>0.05).Conclusions For patients with massive blood loss,the proportion of plasma and red blood cell infusion can be controlled to 1:1,which helps prevent the coagulation dysfunction,and does not have serious influence on the prognosis of patients.