金黄色葡萄球菌肠毒素B功能表位及中和抗体研究进展

金黄色葡萄球菌(金葡菌)肠毒素B(SEB),是造成食物中毒乃至中毒性休克综合征的主要病因。SEB也是一种超级抗原,可以刺激T细胞,能够同时与抗原呈递细胞上的主要组织相容性复合物Ⅱ类分子和T细胞受体上的Vβ结合。随着SEB的结构逐步得到解析,揭示了SEB结构与功能的关键表位。临床上尚无针对SEB中毒的有效疫苗和药物。SEB中和抗体因其高特异性和低毒副作用,成为研究者们的研究首选和重点,从鼠源抗体、人鼠嵌合抗体到人源抗体等均有报道。本文对SEB功能表位及其中和抗体的研究进展进行综述。

Advances in functional epitopes and neutralizing antibodies of Staphylococcus aureus enterotoxin B

Staphylococcus aureus enterotoxin B(SEB),produced by Staphylococcus aureus,is responsible for food poisoning and toxic shock syndrome.SEB is also a superantigen,that can stimulate a large part of T-cells.It can bind simultaneously to major histocompatibility complex class Ⅱ molecules in antigen-presenting cells and to the T-cell receptors that incorporate Vβ chains.As the structure of SEB is gradually analyzed,the key epitopes of the structure and function are revealed.However,no effective vaccine or drug against SEB is in clinic use.Therapeutic antibodies are safe and highly specific with low side effects,which promise to be satisfactory drug candidates.Mouse antibodies,chimeric humanmouse antibodies,and human antibodies et al have been reported.In this paper,we review the functional epitopes of SEB and the development of anti-SEB neutralizing antibodies.