IgG2/IgG4 subclass deficiency in a patient with chronic mucocutaneous candidiasis and bronchiectases |
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| Authors: | C. Brägger R. A. Seger R. Aeppli F. Hallè W. H. Hitzig |
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| Affiliation: | (1) Division of Immunology, Department of Paediatrics, University of Zurich, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland |
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| Abstract: | A 22-year-old man with chronic mucocutaneous candidiasis (CMC) and hypothyroidism developed severe bronchiectases following recurrent bronchopneumonia. Immunological investigations revealed IgG2/IgG4 subclass deficiency and absence of antibodies against pneumococcal and Haemophilus polysaccharides. Under regular immunoglobulin substitution every 3 weeks pulmonary symptoms improved markedly. |
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| Keywords: | Chronic mucocutaneous candidiasis Bronchiectases |
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