| 酶-有机金属催化合成阳离子聚己内酯 |
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| 引用本文： | 汪冬,肖艳. 酶-有机金属催化合成阳离子聚己内酯[J]. 医学教育探索, 2017, 30(4): 450-456 |
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| 作者姓名： | 汪冬 肖艳 |
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| 作者单位： | 华东理工大学材料科学与工程学院, 上海 200237,华东理工大学材料科学与工程学院, 上海 200237 |
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| 基金项目： | 上海市"科技创新行动计划"国际合作项目（14520720600） |
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| 摘 要： | 首先以4-甲酸苄基哌啶内酯（NPIL）为原料,采用钯碳（Pd-C）催化加氢脱保护的方法合成了4-哌啶内酯单体（PIL）;然后以苯甲醇为引发剂,分别采用酶（Novozym 435）和异辛酸亚锡（Sn（Oct）2）催化己内酯（CL）和PIL开环聚合,制备了阳离子共聚物聚（4-哌啶内酯）-co-聚己内酯（P（PIL-co-CL））。通过核磁共振氢谱（1H-NMR）、红外光谱（FT-IR）、凝胶渗透色谱（GPC）、差示扫描量热仪（DSC）等方法对共聚物的结构组成、数均分子量以及热性能等进行了表征。结果表明：成功制备了阳离子聚合物P（PIL-co-CL）,相较于有机金属催化剂Sn（Oct）2,固定化酶Novozym 435催化内酯开环聚合表现出聚合可控且无副反应的优点。
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| 关 键 词： | 哌啶内酯 Novozym 435 开环聚合 |
| 收稿时间： | 2017-03-17 |
Enzyme-Organometallics Catalyzed Synthesis of Cationic Polycaprolactone |
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| WANG Dong and XIAO Yan. Enzyme-Organometallics Catalyzed Synthesis of Cationic Polycaprolactone[J]. Researches in Medical Education, 2017, 30(4): 450-456 |
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| Authors: | WANG Dong and XIAO Yan |
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| Affiliation: | School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China and School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China |
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| Abstract: | 4-Piperidine lactone (PIL) was first synthesized by palladium carbon (Pd-C) catalytic hydrogenolysis using 4-acid benzyl piperidine lactone (NPIL) as the monomer. The cationic poly(4-piperdine lactone-co-caprolactone) (P(PIL-co-CL)) copolymers were further synthesized by enzyme or organometallics catalyzed ring-opening polymerization with benzyl alcohol as initiator, PIL and CL as monomers. The structure, molecular weight and thermal properties of copolymers were characterized by Nuclear Magnetic Resonance spectroscopy (1H-NMR), Fourier Transform Infrared spectroscopy (FT-IR), Gel Permeation Chromatography (GPC) and Differential Scanning Calorimetry (DSC), etc. Results showed that the cationic P(PIL-co-CL) copolymers were synthesized successfully. Compared with organometallic catalyst Sn(Oct)2, the immobilized enzyme Novozym 435 had the advantages of controllable polymerization and no side reaction. |
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| Keywords: | piperidine lactone Novozym 435 ring-opening polymerization |
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