Early effect of sodium valproate and carbamazepine monotherapy on homocysteine metabolism in children with epilepsy |
| |
| Authors: | Attilakos Achilleas Papakonstantinou Evangellos Schulpis Kleopatra Voudris Konstantinos Katsarou Eustathia Mastroyianni Sotiria Garoufi Anastasia |
| |
| Affiliation: | Second Department of Pediatrics, University of Athens, Panagiotis and Aglaia Kyriakou Children's Hospital, 1 Dimitsanis Street, Marousi, 15125 Athens, Greece. attilakos@hotmail.com |
| |
| Abstract: | Plasma total homocysteine (p-tHcy), serum folate (s-F), serum vitamin B-12 (s-B12) and plasma pyridoxal-5'-phosphate (p-PLP) were measured in epileptic children before and after a 20-week period of sodium valproate (group A, n=32) and carbamazepine (group B, n=20) monotherapy. P-tHcy significantly increased in both groups, s-F and s-B12 significantly increased in group A, while s-F and p-PLP significantly decreased in group B. Our study showed an early effect of antiepileptic drug treatment on homocysteine metabolism. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
