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Camel urine inhibits the cytochrome P450 1a1 gene expression through an AhR-dependent mechanism in Hepa 1c1c7 cell line |
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| Authors: | Alhaider Abdulqader A El Gendy Mohamed A M Korashy Hesham M El-Kadi Ayman O S |
| Institution: | a Department of Pharmacology, College of Medicine, King Saud University, Riyadh, Saudi Arabia b Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, Canada c Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia |
| Abstract: | |
| Keywords: | AhR aryl hydrocarbon receptor CYP cytochrome P450 DMSO dimethyl sulfoxide EMSA electrophoretic mobility shift assay 7ER 7-ethoxyresorufin EROD 7-ethoxyresorufin O-deethylase Gapdh glyceraldehyde-3-phosphate dehydrogenase MTT (3-(4 5-dimethylthiazol-2-yl)-2 5-diphenyl tetrazolium bromide) PAHs polycyclic aromatic hydrocarbons TCDD 2 3 7 8-tetrachlorodibenzo-p-dioxin XRE xenobiotic responsive element |
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