妊娠期糖尿病患者胰岛素抵抗与细胞内钙离子浓度变化的关系

为探讨妊娠期糖尿病患者胰岛素抵抗与细胞内钙代谢失常的关系,对32例妊娠糖尿病组及47名正常妊娠组,43名非妊娠组红细胞内Ca2 浓度和红细胞胰岛素受体酪氨酸激酶(TPK)活性进行测定.结果显示,妊娠期糖尿病患者红细胞内Ca2 浓度显著高于正常妊娠组和非妊娠组(P《0.01).相关性分析显示,妊娠期糖尿病患者红细胞内Ca2 浓度与空腹血糖(r=0.418)空腹胰岛素(r=0.367)显著正相关,与胰岛素受体TPK活性(r=-0.874)显著负相关,均有显著性差异(P《0.01).研究表明:妊娠期糖尿病患者红细胞内钙含量变化,可能是导致妊娠期糖尿病胰岛素抵抗的原因之一.

The Relationship between Insulin Resistance and the Chang of Cytosol Free Calcium Concentration in Gestational Diabetes Mellitus

To invesigate the relationship between the inslulin resistance(IR) and abnormalities of cellular calcium metabolism in gestational diabetes mellitus, the changes in the [Ca 2+ ]i and the insulin receptor tyrosine kinase activity in circulating erythrocytes of 32 cases gestational diabetes were compared with those of 47 normal pregnant and 43 non pregnant women.The level of [Ca 2+ ]i in circulating erythrocyte in gestational diabetes mellitus women was significantly higher than that in the pregnant and non pregant women(P<0.01); but the level of insulin receptor tyrosine kisase activity was significantly decreased in gestational diabetes millitus(P<0.01).The [Ca 2+ ]i in circulating erythrocytes in gestational diabetes mellitus was positively correlated with fasting blood glucose and fasting insulin, negatively with the insulin receptor tyrosine kisase activity(P<0.01); The change of [Ca 2+ ]i level during the gastational period might be one of the possible factor in the insulin resistance of gestaional diabetes mellitus.